Yup, it shouldn't have a problem using multiple drives. I was once running 2x WD Raptor RAID 0 and a 40GB Maxtor (ATA133) all at the same time on my Asus A7V8X mobo. But I ended up selling my Maxtor now that I'm running SATA RAID.
<A HREF="http://www.anandtech.com/mysystemrig.html?id=24106" target="_new">My System Rig</A>
<A HREF="http://service.futuremark.com/compare?2k3=535386" target="_new">3DMark03</A>