That would depend on a lot of things but usually it is ok. If you have an older computer that uses SDRAM (has 3 notches on the pin side) then size and alignment doesn't matter at all.
You may only run into problems if you have a newer computer that uses DDR ram(one notch). Then size and alignemnt can affect performance.
Like the other guys said, you can usually mix different amounts of memory with both SDRAM and DDR, mostly older systems though. Any new motherboard will almost require you to install the modules in pairs for best performance although you can install them in different amounts and have them still work. Posting your system specs will also aid us in offering accurate advice.
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www.crucial.com The Memory Experts(SM) at Crucial Technology is now on board to give you straight answers to your memory-related questions.
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