I've been hearing good things about Vipre. It's new to the scene, but the few reviews it has are all near perfect.http://www.pcmag.com/article2/0,2817,2326526,00.asp
Seems user reviews are all perfect. One of the things I find interested about is it actually has a mini virtual-machine. This VM implements only the Windows APIs that allow programs to take over and transparently loads unknown programs into this VM. So it's fast and transparent. It uses heuristics on these APIs and if it deems a program is "bad", it will lock it down before it can do anything since it's playing in their VM.
The reviews it did get gave it just under "Excellent" for detecting *known* virii/malware, but they went on to say it detected ALL real time baddies. So what it marginally lacks in scanning, it makes up in detecting new/unknown malware via heuristics and the VM was the icing on the cake since programs had no chance of modifying anything.
It's also said to be VERY fast. And got a 100% for un-install. Nothing was left, even registry entries. any program that can uninstall correctly gets brownie points from me.
I plan on buying a "Home" Licence which is ~$50 and covers all computers in your house.