You'll be absolutely fine. the only thing you will experience that may be a possible annoyance is the first spinup or each spinup after the drive being idle as you would with any external hard drive. Just means it'll take a couple of seconds for the drive to wake up but after that the USB can handle the bandwidth no problem.
I want to connect my media player device via it's Ethernet port directly to my laptop via an RJ45 cat 5 cable. Does anybody know whether I can do this via an ethernet crossover cable via a direct connection or will I have to buy a hub or a switch. I DO NOT HAVE ACCESS TO MY WIRELESS ROUTER WHICH IS SEQUESTERED IN A DIFFERENT PART OF MY HOUSE (don't ask). Please help.