Yes. Sometimes.
OK, the ONLY difference between FC-PGA and FC-PGA2 is that the later uses a heat spreader on top of the die. Both Coppermine and Tualatin cores are available in FC-PGA2.
A lot of people (including many companies) go under the erronious assumption that all FC-PGA2 processors are Tualatin. While this is wrong, the fact remains that most are. Tualatin's require a newer pin assignment. If your board is Tualatin compatable, either will work. Otherwise you'll need an adapter.
<font color=blue>Watts mean squat if you don't have quality!</font color=blue>