I purchased a Nikon CoolScan LS-10E 35mm slide scanner.
It is expected to be a SCSI attached device. I believe this came out when during the Windows 95 days. I have a Windows 2000, Window XP and Windows 7 machine to work with. i would really like to use it with the Windows 7 but I am not sure it will be possible or cost worth to convert USB to SCSI. I do have a SCSI card I installed on my Windows 2000 machine but I guess I need to find drivers for that because it doesn't look like my system recognized the hardware automatically.
I am searching for the CoolScan drivers online.
Is it even a possibility to get this thing working on a Windows 2000, XP or 7 machine?
USB to SCSI may not work -- some Nikon models explicitly state that they must be directly plugged into a SCSI card.
Once you locate (presumably) Adaptec drivers for Win7 (or XP if you can run XP within Win7), I would redirect your search to Vuescan and Silverfast -- third party scanner software which will drive most scanner models.
I have succesfully used a Coolscan III on windows 7.
Using Vuescan and a Castlewood ORB USB smart card ( SCSI to USB Adaptor).
Plugging the connected USB into my machine Windows 7 found the drivers and it worked.
The only Problem is after dismounting the USB I get an error and all USB ports refuse to work untill a reboot, but thats a small price to pay for a usable Coolscan III.