sounds like a generic program lock-up to me. i've had the mouse disappear on me during these.
you could provide some additional info
-what were you running fullscreen?
-were you multi-tasking when attempting to run?
-do you have an antivirus (which?) and have you done a recent virus scan?
-have you defragmented your hard drive(s) lately? is it (are they) more than 85% full?
-what OS are you running?