what type of setup are you looking for?
if all you want is stereo sound then you could get along with just two bookshelf speakers, integrated or seperate soundcard and a mini amplifier.
if you want surround sound and bookshelf speakers you could get an amp to handle it but personally i would look into a receivers.
for anything in between it could go either way.
i've heard sets from klipsch and they sound great. however the price is a little steep and i dont have room for bookshelf speakers so i bought the satelite speaker set.
there are plenty of other brands out there on the market though.