Run it -- that is the windows utility that checks HDD integrity.
If you think that you have a virus or trojan, then download the free Kaspersky Rescue Disk 10, burn it to a CD and boot your computer from it, then allow it to update, then scan your machine. Get it here: http://support.kaspersky.com/4162
That sounds like a virus issue, nothing should be running from your temp directory, it's actually good that you can't run what it's trying to. There is probably a startup entry that is trying to run that file left over.
A virus scan may not fix that though, find someone that knows computers and ask them to remove this entry.