Your question is kind of difficult without the construction details of the room. If you are doing a 5.1 channel system then putting the speakers on the back wall will work but since they will be quite far behind you they have to be larger than most setups would need. You can use inwalls for this. Getting wire to them is a job for a av installer, electrician, or alarm guy. You can use a wireless transmitter to get the signal from the equipment cabinet to the rear and then only have to run wires from the wireless receiver to the speakers. You may need an amp to drive the rear speakers since this time of wireless setup is usually is not too powerful.