Yes, I have "big" hands.
Not Kareem-Abdul Jabaar or anything, but big enough that finding a sufficiently-sized mouse for comfortable long-term use is a constant challenge.
Any suggestions or advice would be most welcome.
the razer deathadder is a bit beefy. some of the logitechs are also slightly larger than normal. i'm not aware of anything much bigger than them though. if your hands are large you might end up with a fingertip grip instead of palming a mouse like most of us do.