Strange problem, I wonder if any of you have come across this. I've got a friend with a Toshiba L305D-S5934. Occasionally the touchpad and keyboard become completely inoperable while the laptop is in use (a USB mouse will work, however). Oddly enough though, if you let the laptop hibernate, after it "thaws" the keyboard works again.
Laptop has been restored to a previous save, no dice. Device drivers have been replaced and reinstalled, registry has been cleaned... I'm stumped and looking to avoid completely reinstalling Vista.
I too have a problem with a Toshiba Satellite laptop. It is a slightly different model. (L305D-S5974)
I was in the process of projecting the display onto a wide screen tv. I hit the windows option "Display from Projector only". When I did that I couldn't see the mouse anymore on the screen. Looked on the widescreen tv and no mouse either. tried a hard reboot. And like you only way the pointer will work is with an external mouse. Touch pad don't work anymore.
I tried: Scan Disk option, Repairing Driver, Reinstalling Driver, Restore point also, Device hardware restore under F8 Diagnostic Tools and finally factory restore since I had no data i cared about. After it restored to factory out of box. Touch pad still didn't work. So I'm in the same boot now. Still looking for a solution. Berly started today 7/3/2012. I have Windows 7 though.
Did you ever find a solution to the mouse pad issue? Noticed you voiced your complaint in 2010.