Could be a lot of things. Not sure why you put this in drivers though. Is the mouse plugged in? Is the sensor really dirty? Does the keyboard work? Did the mouse battery die (if wireless)? Do other USB ports work? Etc.
No, it's one thing:
The power saver in the power profile.
click system properties
click device manager
double click on mice and other pointing devices
right click on HID compliant mouse
left click on properties
click on the power management tab
UN-check the box that says: "allow the computer to turn off this device to save power." (there is now NO check mark in this box)
Now repeat this procedure for all mice, monitors, keyboards, and ALL USB ports on the device manager list.
You must open ALL the devices one at a time, as above, and turn off the power saver, for each device.
Well sure, it's saving power, alright. by tuning off the mouse. Bloody Clever...