I've just installed 64-bit Windows 7 on an Asus G1S laptop (T5550 @ 1.83 GHz, 4GB RAM). I've been running it for a couple days now.
More often than not, when I click an icon to run an app (either double-clicking the .exe or shortcut icon, or clicking the icon on the quicklaunch bar), nothing happens. There's no hard drive activity, and when I open the task manager, there's no process for the app I've tried to launch, and virtually no CPU usage. As far as I can tell, the computer is completely idle.
Then, about two minutes later, the app will suddenly open. If I had clicked the icon two or three times trying to get the app to open, it will open two or three instances of the app, spaced in time over the same intervals at which I had clicked the icon (two minutes earlier). Once the app is open like this, the performance is fine.
This happens with a variety of apps (Google Chrome, Adobe Flash CS3, different installer .exes, etc.). I believe they have all been 32-bit apps, if that's relevant. I'm also running Symantec Endpoint Protection, so I don't know if that could be related.
Did you perform an upgrade (from Windows Vista or Windows XP) or a custom installation?
If you performed the former, you might be having some issues with certain applications that still are attached to Vista code.
What processes are running in the background?
Also, Microsoft does have an official Windows 7 Support Forum located here http://tinyurl.com/9fhdl5 . It is supported by product specialists as well as engineers and support teams. You may want to also check the threads available there for additional assistance and guidance.