Programs not opening- tried most fixes posted in forums.

Hiyall, been a lurker around here for some time but this is the first time i've asked for help.

I have an Acerbic u36 laptop that just got the black screen of death. I turned it on and tried to log onto my account at first, but my rainmeter background didn't load. "That's strange," I thought, as I restarted it and logged on again. This time, I waited for 30 minutes staring at a black screen, praying for my desktop to load.

Frustrated, I pulled the plug and started it in Safe Mode, and ran Malwarebytes. It got rid of two infections, but didn't fix it. So I turned off User account control (some guy on a forum said this would happen if some drivers were interrupted during installation and couldn't get permission to install) and downloaded the Prevx fix for the black screen, and I started windows normally and ended up with everything loading on startup

. However, programs don't run when I click on them, the computer is running significantly slower than before, the fan sounds like the desperate sobs a man gives as he lies dying in a pool of his own blood and vomit, and Ctrl-Alt-Del give me a black screen.

I am really, really scared and I hope you guys can help me with it. This computer's been through a lot with me and losing it (and all of my video game save files) to some dastardly malware would be an unfitting end.

EDIT: just tried the Doug Knox EXE file association fix, the registry editor gives me an error along the lines of" cannot import, not all data was successfully written to registry, some keys are open by the system or other processes". I'm in safe mode, btw, because the black screen of death is randomly appearing every other time a reboot now.