It sounds like an external drive issue (not a specific drive, but all large drives), as I have used dozens of internal drives on various builds without any issues but rarely use large externals as the transfers are too slow (I use an Icy Dock to hot swap large drives into my main rig to back up bluray images).
Take a look at the drive, attach it and open an elevated command prompt box (right click run as admin) and type fsutil fsinfo ntfsinfo <drive letter>: and see if the drive shows 512 bytes per sector and 4096 bytes per physical sector, which I would expect it will.