What settings are you talking about? Try changing one at a time instead of all at once... When you change more and/or multiply settings, not all of it is changed at once... If you can try one at a time and restart... BTW, what setting you talking about, Games or Windows or others?
My home page and my desktop background go back to the default on reboot. It's getting annoying + plus the window that pops up takes some time to go away!