Applications Keep Crashing

Hi all,
Not to sure whats going on but over the course of the last week everything on my PC one by one has seemed to stop working. For example it start out with Firefox failing to started kept getting a error message saying Firefox has crashed then it moved to WLM then Internet Explorer MS Word ect. So decided to format the PC this morning after doing a virus scan with Malwarebytes and Hitmanpro coming up with nothing.

After reinstalling all my application it has happened again, not to sure what to make of it is it a hidden virus that a antivirus cant find my other thought is a failing hard drive?
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More about applications crashing
  1. Quick update: explorer.exe now seems to be acting up giving a error message System call failed whatever that mean. Just thinking if it was the HDD windows would be giving write/read failures correct?
  2. Double post.
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Windows 7