Removing the DVD drive is probably removing just one screw.
I replaced the DVD drive in my A205 and my A305 Toshibia laptops. Installed a Blu-ray rom/DVD-RW drive in both of them. In the A305 the one screw was inside the Ram compartment. The A205 was on the bottom about 4 in back from the side and center of the DVD drive.
Anyways for Your Model: http://www.irisvista.com/tech/laptops/Toshiba-Satellite-C650-C655/disassemble-toshiba-laptop-1.htm
Step 5 indicates just one screw needs be removed for your Toshiba also.