The 'disk drive' would be your hard disk drive. There is a problem there it seems.
It could be damaged, or the operating system could be messed up, or as jasont78 mentions the HDD might have come loose from it's connector.
A couple things you can do.
Get an external USB adapter for 2.5" HDD and put the hard disk in that.
You can attach it another PC or Laptop by USB port and rescue any data or personal files off the hard disk - as long as the hard disk is working.