uninstalling uni will only make a difference depending on your current PC specs. What other EP's do you have? For instance, Maxis increased the specs when they made NL so instead of the minimum 800Mhz processor, the min is now 1000GHz, so basically you'll need a 2.0Ghz processor to be at mid level range.
To uninstall uni though, go to START, PROGRAMS, EAGAMES, SIMS 2 UNIVERSITY, uninstall, or you can go to CONTROL PANEL, add/remove programs, click the button to remove (uninstall) uni.