I loved Freelancer with the mouse control. What is the best and newest space combat compatible with vista and plays well with a mouse. I have no joystick and no broadband. I want single player. I have 8800gts 640mb card with 6300 cpu.
I find Freelancer to still be fun, but I think it has problems with IPv6 which causes me to get disconnected whilst playing on Vista. I threw it on my XP partition and it works fine.
As for other titles, have you tried X3:The Reunion or even Darkstar One? They're the only ones that come to mind that seem relatively recent.