Well if you have a gamepad with autofire support then you could use a program called xpadder to use the gamepad to simulate the mouse and then autofire with the gamepad as a mouse. But that's a fairly long work around. Can't think of anything else off the top of my head.
Nah you can rapid press on a joypad much faster than you can on a mouse. I remember back in the day when I was a kid playing a game called Warhammer Dark Omen. It was a game like Total War but set in mythological setting and was actually good fun. I had it on the PSX first then later got it on the PC, my point is that on the game you had to rapid press a button on the screen to increase a bar that would make your group fight better. On the PSX I could max that bar with out fail, while on the mouse it was useless I could barely get it half way.
So yeah, unless you can find a mouse with auto fire then your kind of stumped, saying that though I cant see why you would want to rapid click your mouse unless you where using the dual pistols in Counter Strike… but then that would be cheating, wouldn’t it
Simple--stay away from consoles for a while. If you give it enough practice, you can click VERY fast. My own personal trick? Put my middle finger over my index's fingernail... then just tap as fast as you can.
I hate when people use macro's and how its still debated whether or not its really a cheat, it is. Devs need to put some sort of cool down on the semi auto weapons, to keep the damn cheats from Macro'ing a fully auto shot gun.