Nope this is very normal, for the right hand side holes on motherboards esp. These holes are actually not designed for standoffs (you can tell because they don't have the metal ring around them like the other holes should.
The one thing you do need to be careful about is not having too many stand-offs installed. If you have a standoff behind the motherboard which doesn't line up with a hole, make sure it's removed, otherwise it can cause a short which may damage your components.
All the best,