be more specific like what model case you have....
other than that, cooling is not a problem anymore and wont be because of the efficiency since sandy bridge and 6xx/7xxx.
even custom water cooled gpu's dont mean anything anymore since all these newest boosted versions of the current gen cards are voltage locked for now until someone finds a way past that.
just wait for nvidia to release their new stuff in like a month and then you should be able to get a 7970 for like $329 or less and get a simple but good reviewed 600w-650w $60-70 power supply and save the extra money. by the end of the year 1440p monitors will be at $299
4k res power from a gpu is still about 2 years away, even a single titan cant handle 4k, but.... look to see a few 4k hdtv's this holiday season pushed commercially as the new big thing.