can I run a xfx 6600 with a GTS-250 in hybrid SLI mode on a MSI NF980-G65 motherboard. MSI eludes to this when installing chipset drivers etc but eludations freak me out!
I simply won't try to run unmatched cards in general. One of the cards usually bottleneck in such a config, or it might not work that well at all. I don't know if it works or not, but I'd lean towards saying just no, just don't do that.