Mixing monitors with different resolutions - is this a problem?

[Grepawking]

I have 2 24" monitors running 1920x1080 and 2 19" at 1680 x 1050. My video card ASUS GT640-2GD3 GeForce GT 640 has 2 DVI & 1 HDMI & 1 D-SUB. I plan on mounting the 2 24"s next to each other and the 19"s above them (unless someone can suggest different).

My motherboard also has a displayport & HDMI connection and the CPU supports 3 monitors.

IDK if it is possible to mix onboard video and add-on graphic cards or if it is one or the other.

Is it going to be a problem having 2 monitors at different resolutions like this?

 

[legokill101]

no yo cant mix unless you use the graphics card as a display adapter and hteir should not be a problem it just might look weird