Maybe. Your Titan Blacks would essentially work as one video card. The primary limitation to those would be lack of compatibility with a limited subset of professional applications. If you have use for that, you could install the Tesla card and switch between them for specific uses - possibly. Obviously games and renders would go to the Titans as much as possible, anything heavy workload-related. Then the Tesla would be for professional applications. Keep in mind, though, that you'd need software to support such a setup. It would be an exotic solution indeed, and the best way to find out would be to try it.