Either the machine won't start (get post POST) after you increase multiplicator or it becomes unstable (stability tests fail, you get BSOD, Windows won't start...). Case of the machine not getting over POST test should not happen at all, first you do one step increase at time, second motherboards these days are quite smart and if they recognize epic failure, they reset themselves and revert to default settings. If you increase voltage several times and there is still no improvement, you have hit the limit of your cpu. Don't forget to test carefully and watch both stability and temperatures. Personally for last steps I run full load for 12hrs and require zero faults and at least 20°C below threshold (if OCing during summer, 30°C during winter, counting for higher margin for more cooling challenging situation it will have to handle during summer). That's maybe quite big margin, but I don't want it to fail on me when I really wouldn't appreciate it.