Ok its not a problem with the driver, thinking you might need to reinstall as there was a problem with no settings sticking at all.
https://www.techpowerup.com/forums/threads/fixed-ratio-scaling-on-nvidia-cards.197124/
Check you're complying with your monitor's native resolution. Will be a resolution compatibility issue Windows/Nvidia is no accepting for your monitor. Also try lower your resolution see if the option sticks then.