Skype requires headset to work.. headset requires drivers that last time i installed them broke my mouse... mouse/headset made by same people.
What started it all happening? Was hdd always in PC or did you move from old PC? it seems its a permissions issue which is odd unless the hdd is from a previous install, but then the ownership route should work.
If you can access drives from safe mode, then it has to be your user. Its not that hard to swap to a new user, they have just as much access as you and all the programs work for them. Instead of wasting time trying to work out why, just create a new user and if it has access to the hdd, then copy movies off it and format it maybe as then the normal user may see it again. Only things that need setting up are browsers and Onedrive. Bonus to local user is cortana doesn't work. I am using one now.