I use windows Pro10 x64 with dual monitors (running off HD5700 ati card) on a Asus CG5270 with intel Core 2 Quad Q8300 on 4gb ram for my office and I have no issues with windows finding drivers , sure it is not the most performance in a pc in the world, does the job for manual, web browsing and the occasional COD Black ops when I am in the mood. Never had an issue, but like others said, it is possible it may not find drivers for your motherboard and not be surprised when and if it happens, otherwise it will run smoothly on it..