Depends how you feel about having some games not support surround, since a lot do not. I love surround when it works, but just fysa. And yes, it should work; it will also be easier to drive 6400x1080 than what I run (7680x1440), where a single 1080 isn't close to good enough for demanding games. Surround gives great immersion; especially in racing and flight sims and to a lesser extent in third person and first person open world/rpg games. You'll need the Flawless Widescreen program to get some games to look right https://www.flawlesswidescreen.org/ and here is a list of games that support surround at this point http://www.wsgf.org/mgl/ef_s/ .
I will say it would be better if all your monitors have the same height for immersion...