This depends on the monitors rescale function. At my 1440p monitor setting any game to 1080p resolution makes it a bit blurry. That is because of the monitors scaling feature does not show pixel perfect image. I don't know your monitor. You can test it, just play a pc game at 1440p native resolution and then set it to 1080p and compare. If it looks acceptable, then this will be the same with the Switch (I suppose).