If it helps, I too have CAM which I use to configure a Kraken x62 AIO cooler. And I have found something similar, the software works sometimes but most likely after I reboot the program itself doesnt load properly. What I get is the loading progress bar on the screen and it will just sit there not doing very much. The same lighting config is present on my AIO cooler, irrespective of whether CAM loads properly or not.
This behaviour continued for a while, up until about 1 week ago when it managed to start properly and downloaded and installed version 3.5.90. I'd suggest having a look to see if this is either the same version you are running. if version 3.5.90 is newer I'd try searching NZXT's site for it to see if it solves the problem.