Make sure only the drive you are installing Windows is connected. You could insert additional drives later.
Boot from the Windows 10 USB flash drive.
On the Language ,Time and Keyboard selection window click Next.
Click the Install now button.
On the window to enter the product key click the Skip button.
Click on I accept the license terms and click Next.
Select the option Custom: Install Windows only (advanced).
Select each partition in the hard drive and click the X delete button. You will be left with Drive 0 Unallocated Space.
Select Drive 0 Unallocated Space and click the Next button.
Windows 10 installation begins.