Usually the most effective antialiasing is supersampling, or SSAA, which renders the game at a higher resolution and then downscales it. Its a brute-force method and looks great, but the performance hit is usually terrible. Depending on the game, your resolution, and your hardware it may be doable.
SMAA and FXAA are generally the "worst" as far as visual quality, but are have a pretty low performance cost. FXAA in particular can sometimes blur textures quite badly in some games.