Oh, you bet it can!!
The GeForce GTX 480 is the fastest single-GPU solution available right now; but if that's not enough speed for you, then how about putting four of them together?
PC maker CyberPower posted on its Facebook page showing an EVGA setup with four GeForce GTX 480s in a very impressive 4-way SLI setup. According to Techpowerup, EVGA tested the cards on a X58 Classified 4-way SLI motherboard with a special SLI bridge that makes it all possible.
Sadly, no benchmark results yet, but with such a graphical monster on EVGA's hands, we don't imagine details to be secret for very long.