Star Trek Online
AMD HD3D and the TriDef Ignition Driver:
Good 3D result with lowered details or with Virtual 3D mode
Star Trek Online support was fixed in the new 4.6 TriDef Ignition release. There are two ways to run this game using the TriDef driver, but neither is problem-free. In normal mode, the shadow detail is automatically reduced to avoid artifacts, yielding a good result. Unfortunately, you lose the added depth that only proper shadows can add.
Shadows function perfectly in Virtual 3D mode so long as anti-aliasing is disabled. However, the interface is affected by the depth buffer, causing some visual anomalies. Both methods are playable, but users are left to decide which trade-off they find more palatable.
Nvidia 3D Vision:
Good 3D result with lowered details
3D Vision displays anomalies with shadows, anti-aliasing, and bloom in this game. Most of these details can be disabled without issue. However, reducing shadows to the minimum setting really hurts the visual impact of this title, as it does in the TriDef driver's normal mode.
Cryptic recently announced that Star Trek Online is converting to a free-to-play model later this year, in case you're interested in trying this game out.