Conclusion
With our review of PowerColor's Red Devil RX Vega 64 8GB HBM2 complete, it looks like we've tested every Radeon RX Vega 64 card available. There just aren't that many custom designs out there.
PowerColor modified AMD's reference card for its own purposes, adding a great cooler that lives up to the Red Devil reputation. Even if the company tuned this model for cooling performance and not acoustics, the outcome isn't obtrusive. If you want, you can bias the thermal solution to less noise by bumping its temperature target to 70°C or 75°C. You'll have to test this out of course. But if your board is louder than you'd like, it's at least good to know there are remedies.
The Red Devil RX Vega 64's performance is typical of other Radeon RX Vega 64 boards. It's also subject to the same voltage, power, and temperature limits. In other words, there isn't much room for overclocking unless you're willing to overwrite the BIOS with manual optimizations. PowerColor's OC mode is mostly theoretical in nature, just like AMD's own implementation. You might gain a bit of performance, but it comes at the expense of much noise, heat, and excess power consumption. The same disappointing news applies to all Radeon RX Vega-based cards equally.
In the end, PowerColor sends a heavyweight into battle that doesn't become overwhelmed, even under taxing workloads. Its performance is good. The noise is tolerable, even if there are quieter options. Fortunately, you're able to fiddle with software-based settings to make the Red Devil quieter, so long as a slightly higher operating temperature doesn't bother you.
Ultimately, PowerColor's solution hovers around the middle range of Radeon RX Vega 64 pricing, all without asking much in the way of compromise. In that context, this card is a solid choice. But even though it's generally faster than GeForce GTX 1080, Nvidia's closest competitor is currently available at a $200+ savings. We have a hard time recommending any Radeon RX Vega 64 with such a chasm between boards best suited to 2560x1440 gaming.
MORE: Best Graphics Cards
MORE: Desktop GPU Performance Hierarchy Table
MORE: All Graphics Content